diff --git a/lib/mcp/server/transports/streamable_http_transport.rb b/lib/mcp/server/transports/streamable_http_transport.rb
index ef85ef2f..8c1e7020 100644
--- a/lib/mcp/server/transports/streamable_http_transport.rb
+++ b/lib/mcp/server/transports/streamable_http_transport.rb
@@ -1884,8 +1884,9 @@ def validate_accept_header(request, required_types)
         end
 
         def parse_accept_header(header)
-          header.split(",").map do |part|
-            part.split(";").first.strip.downcase
+          header.split(",").filter_map do |part|
+            media_type = part.split(";").first.to_s.strip.downcase
+            media_type unless media_type.empty?
           end
         end
 
diff --git a/test/mcp/server/transports/streamable_http_transport_test.rb b/test/mcp/server/transports/streamable_http_transport_test.rb
index 1e1ebc7a..e48502e5 100644
--- a/test/mcp/server/transports/streamable_http_transport_test.rb
+++ b/test/mcp/server/transports/streamable_http_transport_test.rb
@@ -1756,6 +1756,21 @@ def string
           assert_equal 200, response[0]
         end
 
+        test "POST request with empty members in the Accept header succeeds" do
+          request = create_rack_request(
+            "POST",
+            "/",
+            {
+              "CONTENT_TYPE" => "application/json",
+              "HTTP_ACCEPT" => ", application/json,, text/event-stream",
+            },
+            { jsonrpc: "2.0", method: "initialize", id: "123", params: initialize_params }.to_json,
+          )
+
+          response = @transport.handle_request(request)
+          assert_equal 200, response[0]
+        end
+
         test "POST request with Accept: */* succeeds" do
           request = create_rack_request_without_accept(
             "POST",